Advancing Open Science Through Collaborative Informatics

The i2b2 tranSMART Foundation is a nonprofit organization dedicated to accelerating biomedical research through open-source data integration, analytics, and collaboration platforms. The Foundation supports a global community of researchers, clinicians, informaticians, developers, and institutions working together to enable data-driven discovery and translational science.

By fostering open collaboration and interoperable technologies, the Foundation helps research organizations transform complex clinical, genomic, imaging, and observational data into actionable scientific insights.

Our Mission

Our mission is to empower the global research community with open, scalable, and interoperable informatics platforms that advance translational research, precision medicine, and scientific collaboration.

We believe that accelerating discoveries in healthcare requires:

• Open science and transparent collaboration
• Community-driven innovation
• Standards-based interoperability
• Secure and responsible data sharing
• Accessible tools for researchers and institutions of all sizes

What We Support

The Foundation supports and promotes technologies and initiatives that help organizations:

• Integrate heterogeneous biomedical data sources
• Perform cohort discovery and feasibility research
• Enable translational and clinical research workflows
• Support federated research networks
• Accelerate AI and machine learning research readiness
• Facilitate secure collaboration across institutions
• Advance reproducible and scalable biomedical informatics

These technologies are used across academic medical centers, hospitals, research institutes, government organizations, and industry partners worldwide.

A Global Community

The Foundation is built on a collaborative global community of:

• Academic medical centers
• Healthcare organizations
• Government agencies
• Research consortia
• Industry collaborators
• Open-source contributors
• Biomedical informatics professionals

Community members contribute through software development, governance participation, working groups, implementation support, scientific collaboration, and shared innovation.

Open Source and Interoperability

The Foundation is committed to open-source principles and interoperable research ecosystems. Our community actively supports:

• Standards-based integration approaches
• Flexible deployment models
• Modern APIs and extensibility
• Collaboration across research platforms
• Integration with emerging AI and analytics technologies

This commitment enables institutions to build sustainable research infrastructures while maintaining flexibility for future innovation.

Governance and Sustainability

As a nonprofit organization, the Foundation is guided by a community-oriented governance model focused on transparency, collaboration, and long-term sustainability. The Foundation works to ensure that its platforms remain community-driven, vendor-neutral, and aligned with the evolving needs of biomedical research.

Support from member institutions, contributors, sponsors, and volunteers helps sustain ongoing development, community engagement, educational initiatives, and platform evolution.

Join the Community

Whether you are a researcher, developer, institution, or industry partner, the i2b2 tranSMART Foundation welcomes collaboration and participation.

Together, we are building open, connected, and scalable informatics solutions that help accelerate scientific discovery and improve human health.